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[1] [2] This reduces the risk of hypoglycaemia when used alone, though this risk increases significantly when combined with insulin or sulfonylureas

Despite the constant exposure of mitochondria to oxidant species, an effective antioxidant defense system, in which mitochondrial GSH (mGSH) plays a pivotal role, mitigates or repairs oxidative damage incurred during normal aerobic metabolism

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This work was funded by the European Research Council (ERC-CoG 101044445), the German Research Foundation (DFG TRR296, TRR152, SFB1123, GRK 2816/1), the German Center for Diabetes Research (DZD), and NIH grant R01DK133140 (to R.J