why discard semaglutide after 28 days Does GLP-1 Expire Days? Storage Guidelines Explained FAQ from the medSask lines

Although the reimbursable market for liraglutide was short-lived in the UK as semaglutide became the preferred GLP-1 agent, the experience with generic liraglutide saw rapid uptake by distributors with online pharmacy channels

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The biggest concern around the safety of microdosing is if patients are doing it without the knowledge of their treating team (such as their GP, dietitian, and pharmacist)

Athletes using semaglutide for authorized medical reasons should maintain documentation, and athletes considering GLP-1 medications without medical need should be aware that the regulatory status may change

Theres a chance that lower-than-standard doses might help a subset of patients, but if true, its likely that the doses would be among the lower doses already tested by the drug companies