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Tirzepatide remained the leading AOM and ADM by prescription volume and showed the largest increase in total prescribing from September to December 2025

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MAJOR FEATURES OF THE LESION (2 points each): Change in size Irregular shape Irregular colour MINOR FEATURES OF THE LESION (1 point each): Largest diameter 7mm or more Inflammation Oozing Change in sensation Patients should also be referred urgently (within 2 weeks) if dermoscopy suggests melanoma skin cancer and if a pigmented or non-pigmented skin lesion is suggestive of nodular melanoma or other forms of rarer skin cancers