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These detailed cascades, while well-documented in the cited literature, are proposed as hypothetical frameworks to explain the functional consequences of the target downregulation we observed, and they require direct experimental confirmation in the context of palmatine treatment

Dtsch Arztebl Int 108(47):795801

In the databases of adverse drug events in multiple countries, the number of reports of mood changes, suicidal ideation and depression related to GLP-1RA has been on the rise, prompting regulatory authorities to request further monitoring [13, 15, 26, 27]