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Prospective studies, such as the UK Prospective Diabetes Study (UKPDS) demonstrated that T2D is a progressive disease that worsens over time, whatever the pharmacological management used to reduce daily glucose excursion

Similarly, Li and colleagues reported that electrical stimulation (ES) increased the amount of collagen, activated integrin 1, regulated TGF-1 to prevent apoptosis, and increased the calcium level in podocytes (Li et al

b Estimated using an ANCOVA model based on data irrespectively of discontinuation of trial product or initiation of rescue medication adjusted for baseline value and region

J Cell Biol 216(7):20912105