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Because vitamin B12 has action at the cellular level and is in charge of multiple pathways where a deficiency may lead to the subjective feeling of fatigue or low energy

It is a growth hormone secretagogue that works by binding to the ghrelin receptor (GHS-R) in the pituitary gland and hypothalamus ,the same receptor targeted by the hunger hormone ghrelin

Optimizing hormone levels through bioidentical hormone replacement therapy (BHRT) dramatically improves body composition, energy, mood, and long-term health outcomes

A 60% decline over four decades