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A meta-analysis of 56 studies examining MTHFR C677T in patients and control subjects indicated that the T allele and TT genotype carriers showed significant increased risk of major psychiatric disorders including schizophrenia and bipolar disorder 63

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These pancreatic effects are complemented by improved peripheral insulin responsiveness in muscle tissue and lipid storage sites, facilitating glucose disposal and reducing systemic insulin resistance - a key driver of hepatic lipid accumulation and MASH progression [28,31]

All references are to research contexts only

Nevertheless, these panels still provide a limited genomic perspective, often lacking the scope and precision required for individualized interpretation (Villalba et al., 2023)