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[6] If it is given by injection into a vein without making it approximately isotonic, breakdown of red blood cells may occur

Curran-Everett, D

Gating residues involved in the occluded-to-inward conformational transition of OCTN2 Alternating-access transport by secondary active transporters requires the coordination of gates that enclose or preclude access to the substrate-binding site from either side of the membrane 51

studies have shown a 0.6% A1C decrease after approximately 6 months of sitagliptin or alogliptin therapy, compared with 0.5% for saxagliptin and 0.4% for linagliptin

However, this was not a statistically significant difference, which may be attributed to the relatively small sample size