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The American College of Medical Genetics and Genomics has also included HT-1 in the core panel of conditions for which every newborn in the United States should be screened

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Actions at receptors other than D2, 5-HT1A, and 5-HT2A could explain some of the other adverse reactions of aripiprazole (e.g., the orthostatic hypotension observed with aripiprazole may be explained by its antagonist activity at adrenergic alpha1 receptors)