Mutations in PDSS2, COQ6 , and ADCK4/COQ8B affect mainly the kidney by inducing steroid-resistant nephrotic syndrome while COQ2 mutations induce multisystem disorders whose severity correlates with the mutated genotype (Desbats et al., COQ4, COQ7, COQ9 , and/or PDSS1 develop encephalopathy and those affected by mutations in ADCK3/COQ8A develop mainly cerebellar disorders
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Finally, the biology of non-response and therapeutic resistance - including the role of gut microbiome composition, adipose tissue dysfunction phenotypes, and genetic determinants of drug metabolism - represents a frontier for translational investigation to improve patient outcomes
Individuals with sensitive skin may benefit from patch testing before regular use
The most common include nausea, constipation, diarrhea, appetite changes, reflux, or feeling full very quickly