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Side effects of topical retinoids include redness, dryness, and itchy skin

Sunazuka Y, Ueda K, Higashi K, Tanaka Y, Moribe K

9 The researchers also noted that sublingual B12 has many practical advantages over injections, which are painful, costly, and require repeated clinic visits

The most common effects are mild injection site reactions (temporary redness or slight discomfort), occasional mild water retention (often temporary and dose-dependent), rare reports of mild tingling or numbness in extremities (usually transient), mild increases in hunger in some subjects (less common than with GHRP-6), and occasional mild headaches (often resolve quickly)

Antioxidants can increase melanoma metastasis in mice