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The keystone discovery initiated an era of mitochondrial pathology in PD

Endogenous synthesis of lipoic acid The figure illustrates the mitochondrial de novo synthesis of lipoic acid, starting with the formation of octanoic acid in the acyl-carrier protein (ACP)-dependent fatty acid synthesis pathway

Furthermore, concerns about the long-term effects of RhoGAM on children who are Rh-negative (who therefore do not need the protection) remain underexplored

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This method is simple and sensitive, but has poor specificity