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This naturally occurring antioxidantglutamine, cysteine, and glycineis essential for protecting cells against oxidative damage

A higher ratio of GSH to GSSG suggests a reductive environment where ROS levels are kept at homeostatic levels, whereas a low GSH to GSSG ratio is indicative of oxidative stress [61]

GSH acts by scavenging reactive oxygen species (ROS) and chelating intracellular zinc (Zn), whose dysregulation exacerbates neuronal injury and contributes to ischemic cascades (10)

PMCID: PMC5239707

Free radicals and other oxidants are reduced by the direct action of GSH and indirectly via enzyme glutathione peroxidase, which use GSH as a cofactor