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These agents may potentially increase the risk of recurrence or worsen prognosis

Diminishing returns and plateaus: Each successive cycle typically produces less dramatic changes than the first

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The critical difference from other GHRPs is that ipamorelin achieves maximal GH release at doses that do not significantly activate GHSR on corticotroph cells (which would release ACTH/cortisol) or lactotroph cells (which would release prolactin)

Weight Gain: Rarely, receiving large doses of glutathione injections may also result in weight gain