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Authors contributions All authors of this work have contributed to the planning and performing of the study as well as to writing and revising of this paper

Specifically, the tumor metabolite lactate regulates the stability and function of Treg cells through lactylating MOESIN at lysine 72, enhancing its interaction with TGF- receptor I and activating downstream SMAD3 signaling

Shi ZZ, Habib GM, Rhead WJ, Gahl WA, He X, Sazer S, Lieberman MW: Mutations in the glutathione synthetase gene cause 5-oxoprolinuria

Once inside the cell, the acetyl group is removed, releasing active glutathione where its needed most

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