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doi: 10.1002/jcp.30582 54 FengDZouJSuDMaiHZhangSLiPet al

The maintenance of skeletal homeostasis relies on the precise balance between osteoclast mediated bone resorption and osteoblast mediated bone matrix formation, When the rate of bone resorption is faster than the rate of bone formation, the skeletal homeostasis is disrupted, leading to bone loss and OP ( The human gastrointestinal tract is home to over 100 trillion bacterial cells and 3 million genes, forming an extremely large microbial community ( Gut-bone axis, the evidence of interaction between GM and OP Mounting evidence has shown the relationship between GM and bone metabolism, highlighting its potential influence of GM in OP pathogenesis

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Step 4: Mix the Solution Gently inject the solvent into the vial containing the Selank powder