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doi: 10.1073/pnas.0605652103

Subsequently, we will employ a GPX4 inhibitor (RSL3) and an iron death inhibitor (ferrostatin-1) to elucidate whether the effect of HT is contingent upon the Nrf2-GPX4/ACSL4 axis

Methods The study used data from adults ( 18 years) with T2D who were included in the IBM MarketScan Explorys Claims-EMR Data Set for 180 days pre-index and 365 days post-index, were GLP-1 RA and insulin nave at first claim (index date) for once-weekly or daily injectable GLP-1 RAs (follow-up: index date + 365 days), and were propensity score (PS) matched 1:1 by baseline characteristics