In certain embodiments, diffusion of at least one otic agent from the formulation or composition occurs for a time period exceeding 5 minutes, or 15 minutes, or 30 minutes, or 1 hour, or 4 hours, or 6 hours, or 12 hours, or 18 hours, or 1 day, or 2 days, or 3 days, or 4 days, or 5 days, or 6 days, or 7 days, or 10 days, or 12 days, or 14 days, or 18 days, or 21 days, or 25 days, or 30 days, or 45 days, or 2 months, or 3 months, or 4 months, or 5 months, or 6 months, or 9 months, or 1 year
In some embodiments, the otic formulation or composition comprises about 40% by weight of the viscosity modulating agent(s)
doi: 10.1186/s13643-016-0384-4 41 PageM
Individuals who lack intrinsic factor have no ability to absorb vitamin B 12
At 2mg three times weekly, your 100mg vial provides approximately 16-17 weeks of supply, well over the typical 8-12 week cycle length