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Ethanolic extract of okra has a potential gastroprotective effect on acute gastric lesions in Sprague Dawley rats

Published pharmacokinetic research indicates that orally administered berberine, for example, faces substantial first-pass metabolism that may affect the amount reaching target tissues.

Pages-Puigdemont N, Mangues MA, Masip M, et al

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A slower emptying rate can lead to prolonged gastric distension, increasing the likelihood of stomach contents, including acid, flowing back into the esophagus