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Description

The pathogenesis of vitiligo has been associated with the XBP1 gene, a transcription factor that plays a crucial role in endoplasmic reticulum stress response and regulates HLA class II gene expression.51 In the Chinese population, HLA-DQB1 and HLA-B have been identified as associated risk factors

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have shown that inhibition of PSC activation is associated with a decrease in islet fibrosis and an increase in insulin secretion [35], indicating the potential role of PSC activation in -cell failure

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