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Lastly, to evaluate the robustness of the associations detected, we additionally included data collected from NESDA subjects still available at 6-year follow-up by pooling all observations (N = 4141) in a unified mixed model with two random factors (one for the family effect and one for the repeated observations from the same subject over time)

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Many clinicians actively recommend PPI therapy for semaglutide users with significant reflux symptoms

This represents a shift toward making life-changing metabolic treatments more accessible and easier to integrate into daily life and I suspect the beginning of small molecule GLP1 agents

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