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337,338 Structural mitochondrial abnormalities such as disrupted cristae are widely documented in FTLD-TDP, AD, mixed AD/PD, and HD, linking altered mitochondrial architecture to impaired ATP production, calcium dysregulation, synaptic dysfunction, and eventual neuronal death

Various supervised models, including kNN, Logistic Regression, Nave Bayes, Neural Network, and Random Forest, were utilized for the ROC tests 60

**Decreased Pain and Improved Sleep** BPC-157 has also been shown to decrease pain and improve sleep in this study