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Thigh: If you choose your thigh as an Ozempic injection site, select a spot on the outer side of your upper thigh, roughly halfway between your knee and hip

Most of these effects are worst during the first few weeks at each new dose level and typically improve significantly after 2 to 3 weeks of consistent dosing

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James Carter, MD Last Updated: July 2026 A Semaglutide weight loss dosage chart typically starts at 0.25 mg once weekly and rises in stages toward a higher maintenance dose over several months