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4 Evidence suggests that barriers to prescription involve interplay among safety concerns, doubts about efficacy, lack of insurance coverage, need for long-term use, and the persisting perception of obesity as a behavioral problem

Sleep apnea : Causes pauses in breathing and fatigue, while increasing the risk of high blood pressure and heart disease

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However, the issue of rebound upon drug withdrawal remains an unmet need in the GLP-1R agonist space, says GlobalData

The pathways that transduce GLP-1RAmediated reduction of BP are not well defined, and kidney-centric mechanisms such as inhibition of tubular salt reabsorption, vascular inflammatory immune cell infiltration, central regulation of vascular tone, and either EC- or VSMC-regulated vasodilation have been proposed (33)