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A 2024 meta-analysis of 6 randomized controlled trials involving 1,529 women with diminished ovarian reserve found that CoQ10 pretreatment significantly improved clinical pregnancy rates (OR 1.84), increased the number of retrieved oocytes, improved embryo quality, and reduced both cycle cancellation and miscarriage rates ( Lin et al., Annals of Medicine , 2024 )

Appetite changes are less consistently reported with AOD-9604 than with semaglutide and in controlled studies, most short-term safety signals mirrored placebo rates