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Acknowledgments BD and MV are founded by the Center Scientifique de Monaco (CSM) and the Monegasque association GEMLUC (Groupement des Entreprises Mongasques dans la Lutte contre le Cancer)

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Endotoxin testing (LAL test): For any application involving live cell systems, endotoxin levels must be assessed via the Limulus Amebocyte Lysate (LAL) test

Exendin 939 does not affect TRPV1 activation via protons, suggesting its mode selectivity As the inhibitory effect of exendin 939 on CAP-induced activation of TRPV1 was confirmed, its effect on proton-induced activation of TRPV1 was also tested via patch-clamp recordings and calcium imaging