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And preclinical models consistently show benefits for Alzheimers-like pathology. In addition, a combination of their anti-inflammatory effects and effects on the vasculature likely explain some of the beneficial effects on dementia reported in observational studies, Holst says

Wegovy (semaglutide) is a once-weekly GLP-1 receptor agonist injection with a half-life of approximately one week

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Conclusions This real-world health economic evaluation along with a comprehensive systematic review suggest that the use of a GLP-1RA versus insulin has a high likelihood of being cost-effective for T2D patients who require intensified injection therapy from a third-party payer, healthcare sector, and societal perspectives