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SCFAs stimulate the proliferation of colonic epithelial L cells and are bound to GPR43 above them, increasing intracytoplasmic calcium ion and cyclic adenosine cAMP concentrations and increasing GLP-1 secretion (Chambers et al., 2018

Besides, it stimulated expression of early growth response 1 (egr-1) gene responsible for cytokine and growth factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve growth factor 1-A binding protein-2 (nab2)) (44)

And the industry reaction is always the same: Is this the next semaglutide? Wrong question

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