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Together, these findings raise the possibility that the collective action of multiple 22q11.2 genes determines the behavioral phenotype, consistent with the concept of a contiguous deletion syndrome, and that some genes deleted in 22q11DS may have antagonistic effects, all of which likely influence phenotypic expression

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Research published in the Journal of Oral Biology and Craniofacial Research pointed to significant pain relief with B12 supplementation used as part of a holistic pain management approach