The dried residues were dissolved in water, in which 1 10 4 cells/ 5 L were used for the phi29 polymerase-based RCA reaction mixture
Injections are favored for severe deficiency, malabsorption (e.g., postGI surgery, chronic diarrhea), very low B12 levels with neurologic signs, poor adherence, or when rapid repletion is needed
B12 injections are generally well-tolerated with mild injection site reactions, though rare hypersensitivity and hypokalaemia can occur, particularly when initiating treatment for severe deficiency
Note the RPE and outer retinal destruction over the heterogeneous changes of the superior and temporal region
Fatigue or Dizziness Some individuals report temporary fatigue, lightheadedness, or low energy early during treatment