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Of note, pharmacologically induced PFC NMDAR hypofunction leads to increased oscillations [99] while genetic deletion of NMDAR1 subunits in pyramidal neurons increases oscillations, cell excitability and sEPSC frequency [100], similar to the present data

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Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those using diuretics concomitantly and the elderly