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Safety and tolerability of increasing doses of CB-839, a first-in-class, orally administered small molecule inhibitor of glutaminase, in solid tumors

Additionally, NRF2 regulates the expression of enzymes such as glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), malic enzyme 1 (ME1), and isocitrate dehydrogenase 1 (IDH1), which are involved in generating reduced nicotinamide adenine dinucleotide phosphate (NADPH), a crucial cofactor for antioxidant reactions (Wu et al

DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer

Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFB/NLRP3 inflammation signal pathway

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