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The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)

Wegovy, on the other hand, is a GLP-1 receptor agonist that mimics the natural hormone GLP-1, which plays a key role in appetite control

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As of July 1, 2026, eligible Medicare Part D beneficiaries can access three FDA-approved GLP-1 medications for chronic weight management at a flat $50 per month medication copay