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Dysbiosisan imbalance in microbial diversitycorrelates with obesity and reduced GLP-1 receptor expression in the gut lining

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Given the lifesaving nature of epinephrine, any potential interaction with GLP-1 drugs is a serious concern

As a consequence, levels of adherence are lower than for people with diabetes, as demonstrated by another study that applied the same metric of adherence to people using GLP-1s to treat obesity: 40.1% for Ozempic (semaglutide, Novo Nordisk), 31.5% for weekly injectable Wegovy and just 15% for daily injectable Saxenda (liraglutide, Novo Nordisk).10 This suggests that greater expectation management is required to maintain users faith in the value and purpose of what they are doing