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Our study highlights a significant upward trend in the deployment of DHTs in interventional trials for selected rare diseases, particularly since 2020 (Fig

Because ERT clinically improves the disease and symptoms but is suboptimal due to the occurrence of irreversible renal injury in cases of late diagnosis 22 , our findings are compatible with the natural clinical course of human Fabry disease

These states exacerbate and maintain endothelial dysfunction, impairing vasorelaxation events and cavernosal blood perfusion, which are crucial for normal erectile function

When experiencing symptoms of dizziness or lightheadedness, patients should check their blood glucose to differentiate hypotension from hypoglycemia, as symptoms can overlap