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A recent 2022 Phase 2 randomized, double-blind, placebo-controlled trial funded by the NIH evaluated the effects of D-Ribose and Ubiquinol in patients with heart failure with preserved ejection fraction (HFpEF)

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Histological analysis of skin biopsies from GHK-Cu-treated subjects has confirmed increases in collagen density, normalization of elastin structure, improvement in dermal architecture, and increased glycosaminoglycan content - objective evidence of tissue-level improvements beyond subjective appearance

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