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They stimulate dermal fibroblast activity through pathways that operate independently of the GLP-1 receptor
The analysis looked at serial trial data outcomes
Hell J Nucl Med 17(1):3740
however, in this case, the participants analyzed were recreational athletes
Activation of both GIP and GLP-1 receptors by retatrutide probably contributed to the observed changes in circulating triglycerides, as treatment with the dual GIP/GLP-1 receptor agonist tirzepatide significantly reduced triglyceride levels by up to 29% at 52 weeks in a clinical trial in people with T2D and MASLD 8
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