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In the SOUL randomized clinical trial on oral semaglutide, for example, all participants taking semaglutide experienced clinically significant drops in blood pressure

This timeframe coincides with the body's adaptation to the medication's effects on gastric emptying, appetite, and glucose regulation

In 2022, the FDA added Wegovy (semaglutide), Ozempic (semaglutide) and Mounjaro (tirzepatide) to the FDA drug shortage list, followed by Zepbound (tirzepatide) in 2024

Co-primary endpoints encompassed the percentage alteration in body weight from baseline to week 104 and the attainment of weight loss equivalent to or greater than 5% of baseline weight at week 104

When injections may be better You want treatments backed by strong clinical trial data