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In a preclinical study on murine melanoma models, estrogen signalling through estrogen receptor alpha (ER) promotes the polarization of TAMs toward an immunosuppressive M2 phenotype, which impairs cytotoxic T-cell function and limits ICI efficacy

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Epithalon structure and discovery Chemical composition: Tetrapeptide (four amino acids) Sequence: Ala-Glu-Asp-Gly (AEDG) Also called Epitalon or Epithalone Synthetic version of epithalamin (pineal gland extract) Molecular weight: 390.35 g/mol Water-soluble peptide Discovery history: Discovered by Professor Vladimir Khavinson in St