It is suggested that it acts on receptors in the area postrema (AP), 135 although the highest density of amylin binding sites (modified calcitonin receptors, AMY1-3) occur in the hypothalamus
[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL
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Like other GLP-1 medications, such as Wegovy or Mounjaro, the most widely reported side effects with retatrutide so far are gastrointestinal