Published studies describe its interaction with growth-hormone-related signaling systems in research settings
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
The effects of GLP-1s increase postprandial insulin secretion from pancreatic -cells, suppress glucagon secretion from -cells, slow gastric emptying, and reduce appetite (Gross)
It could manifest as worsening B12 deficiency symptoms like skin rashes, tingling sensations, burning pain, tremors, heart palpitations, joint pain, and more
TRANSCEND-T2D-1 reported results on March 19, 2026 the first Phase 3 diabetes readout: These trials are expected to further broaden retatrutide's potential label across metabolic, musculoskeletal, and liver disease indications