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In clinical trials conducted using the once to weekly subcutaneous semaglutide injection, combined with lifestyle interventions, participants treated with semaglutide demonstrated greater reductions in body weight at least 15 percent of their baseline body weight compared to those who received a placebo

This can also happen with other GLP-1 medications, like tirzepatide, as well

The delayed gastric emptying induced by these medications creates a mechanical component to satiety

The proteomic signature of semaglutide could possibly serve to assess intentional and nonintentional nonadherence with prescribed treatment, especially in those with modest weight loss 47

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