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In summary, we put forward that targeting mature OLs is an untapped therapeutic avenue to support CNS health in the context of neurological disorders

Hernandez LE, Sobrino-Plata J, Montero-Palmero MB, Carrasco-Gil S, Flores-Caceres ML, Ortega-Villasante C, Escobar C

The third pathway is proline utilisation which occurs in mitochondria where proline is oxidised to pyrroline-5-carboxylate by mitochondrial proline dehydrogenase ( PUT1 ) which, in turn, is further oxidised to glutamate by 1-pyrroline-5-caboxylate dehydrogenase ( PUT2 ) 19