Experimental models of metabolic syndrome also show that, besides the regulation of MAPK, other transcriptional factors such as peroxisome proliferator-activated receptor gamma (PPAR), CAAT/enhancer binding protein- (C/EBP) and sterol regulatory element binding protein (SREBP)-1c are increasingly studied for their role in adipogenesis and lipid-induced hepatic toxicity [31,34,35]
Supporting this, data from our functional enrichment analysis of the transcriptome revealed notable upregulation of oxidative phosphorylation and the oxidative damage response in hepsin / mice treated with saline (data not shown)
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