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10 Discussion Cancer is the leading cause of death and immunotherapy has attracted a wide range of attention due to its advantages such as durable response, long-term survival benefit, and lower toxicity and side effects (242, 243), in which immune cells are the target cells for immunotherapy, which as part of the TME are mainly composed of TAMs, DCs, NK cells, TANs, MDSCs and T cells
The primary endpoint was a composite of all-cause mortality, myocardial infarction, stroke, coronary revascularization, and hospitalization for angina [111]
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Similarly, lymphocytes from subjects exposed to radiation 32-41 years prior to blood collection were found to have significantly increased chromosome-type aberrations (acentric fragments, dicentrics and translocations) and MN relative to unexposed controls (Han et al
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