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The presence of PML bodies characterises ALT activity in cells (Chung et al 2012)

F.ChenH.et al

The effect of excess I on thyroid follicular cells (TFCs) obtained from HT patients resulted in inhibition of autophagy, autophagy-associated protein LC3B-II (lain chain 3B-II), TGF-1, and increased ROS production, caspase-3 activation and apoptosis of TFC, the Akt/mTOR signaling pathway (46)

Cycle smart: many practitioners recommend 812 weeks on, followed by a 8-12 week break to allow natural remodeling before restarting

The 2024 Yang paper in Journal for ImmunoTherapy of Cancer documented NNMT in cancer-associated fibroblasts driving tumour progression (PMID 39067875)