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Therapeutic interventions to block oxidative stress-associated pathologies
[4] As a result, GLP-1 agonists are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or those with multiple endocrine neoplasia syndrome type 2 (MEN 2), a genetic disorder that increases the risk of certain types of tumors
Protein aggregation in amyotrophic lateral sclerosis
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16 Obesity also promotes persistent inflammation, which causes fibrotic tissue to infiltrate muscles 7 and surrounding connective tissue, impairing tissue structure thus decreasing the release of myokines and the cascade of positive effects they have on glucose regulation
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