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The evidence base is more mechanistic than clinical at this point

doi: 10.3389/fphar.2021.767975 Received 02 September 2021 Accepted 11 October 2021 Published 26 October 2021 Volume 12 - 2021 Edited by Diego A

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Unlike some other GHS peptides, Ipamorelin does not significantly increase appetite (a common side effect of ghrelin receptor activation) at the doses typically used in research protocols

Considering extensive previous studies reporting that PVN neuronal activity is closely associated with gastrointestinal function 27,28 , we performed immunofluorescence staining to identify the neuronal types in the PVN marked by EGFP: ~ 92% of EGFP + cells were co-stained with a glutamate-specific antibody, while only 12% of EGFP + cells were co-localized with a GABA-specific antibody (Fig