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Thus, peptides with cytolytic effects are usually combined with other peptides capable of directly recognizing cancer cells [48]

Glutathione, often hailed as the master antioxidant, has gained popularity for its potential benefits, from skin lightening to immune support

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It belongs to the ghrelin mimetic peptide class

For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of 10 mM, which is approximately ten times higher than that in normal cells ( In general, elevated GSH can be observed in many cancers, including lung cancer, ovarian cancer, breast cancer, and head-neck cancer, and this adaptive upregulation of GSH has various effects on tumor advancement, metastasis, and drug resistance (Wong et al., 2016)