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validation, Olinda Nez Murillo, Nusly Andres Montenegro and Sidnee Molina Gutierrez

These factors collectively form a complex regulatory network that influences the equilibrium of iron ions and the cellular health status

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Comparative evaluation of these analogs alongside DJX-A-KM at a lower concentration (20 nM) revealed that both increases and decreases in electrophilicity compromised KRAS G12C degradation efficiency to varying degrees, with DJX-A-KM remaining the most potent, achieving ~80% degradation (Fig